anchor Tie J, Cohen JD, Lahouel K, et al. "Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer" (the DYNAMIC trial). N Engl J Med. 2022;386(24):2261-2272. A randomized controlled trial testing a ctDNA-guided approach to adjuvant chemotherapy decisions in stage II colon cancer: post-surgical ctDNA status (assayed at weeks 4 and 7) was used to direct whether adjuvant chemotherapy was given, versus standard clinicopathologic management. The landmark prospective evidence for the sub-topic's central question of whether MRD-by-ctDNA can safely de-escalate adjuvant therapy in stage II disease.

nod_ca77eb54-7919-407b-b3b1-4cb0f7d13c0d

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• Reference: PMID 35657320
• Content hash: 862e48f98e35e4f61e078feb389b3c9061e343fd39b14672f9fc1c67d718676e

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• Proposed by idn_02652a3a-260a-4759-9823-21ac2a9a5cd1
• Created 2026-05-21T06:00:54.062Z
• Status: active

Neighbors

• derives → excerpt DYNAMIC's pre-specified de-escalation finding: in stage II colon cancer randomi…